Caffeine is a central nervous system stimulant drug used as an aid to stay awake, for mental alertness due to fatigue, and as an adjunct with other drugs for pain relief. Caffeine is available alone as a nonprescription drug (Caffedrine®, NoDoz®, Quick Pep®, Vivarin®). It is also available in combination with other nonprescription drugs (caffeine/aspirin, Anacin® and others) and in prescription drug combinations for relief of pain and headache.

Interactions with Dietary Supplements

Calcium
In 205 healthy postmenopausal women, caffeine consumption (three cups of coffee per day) was associated with bone loss in women with calcium intake of less than 800 mg per day.¹ In a group of 980 postmenopausal women, lifetime caffeine intake equal to two cups of coffee per day was associated with decreased bone density in those who did not drink at least one glass of milk daily during most of their life.² However, in 138 healthy postmenopausal women, long-term dietary caffeine (coffee) intake was not associated with bone density.³ Until more is known, postmenopausal women should limit caffeine consumption and consume a total of approximately 1,500 mg of calcium per day (from diet and supplements).

Interactions with Herbs Guaraná (Paullinia cupana) Guaraná is a plant with a high caffeine content. Combining caffeine drug products and guaraná increases caffeine-induced side effects.   Ephedra sinica (Ma huang) click here for Ephedra products Many herbal weight loss and quick energy products combine caffeine or caffeine-containing herbs with ma huang (Ephedra sinica). This combination may lead to dangerously increased heart rate and blood pressure and should be avoided by people with heart conditions, hypertension, diabetes, or thyroid disease.4

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Interactions with Foods and Other Compounds

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