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Chondroitin Sulfate
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What does it do? Chondroitin sulfate consists of repeating chains of molecules called mucopolysaccharides. Chondroitin sulfate is a major constituent of cartilage, providing structure, holding water and nutrients, and allowing other molecules to move through cartilage—an important property, as there is no blood supply to cartilage.

Animal studies indicate that chondroitin sulfate may promote healing of bone, which is consistent with the fact that the majority of glycosaminoglycans found in bone consist of chondroitin sulfate.1 Chondroitin sulfate also appears to help restore joint function in people with osteoarthritis,2 a finding confirmed in double blind research.3 4

Chondroitin and similar compounds are present in the lining of blood vessels and the urinary bladder. They help prevent abnormal movement of blood, urine, or components across the barrier of the vessel or bladder wall. Part of chondroitin’s role in blood vessels is to prevent excessive blood clotting remains unclear. However, whether supplements of chondroitin are able to favorably affect blood clotting. In addition, chondroitin sulfate may lower blood cholesterol levels.5 Older preliminary research showed that chondroitin sulfate may prevent atherosclerosis in animals and humans and may also prevent heart attacks in people who already have atherosclerosis.6 7 8

Chondroitin sulfate can help form a coating on nasal passages. Perhaps as a result, researchers found that when chondroitin sulfate was sprayed onto nasal passages in a small group of snorers, the amount of time people spent snoring was reduced about one third in a double blind trial.9 No further studies have investigated the effects of oral chondroitin sulfate on snoring.
Chondroitin sulfate sulfate is classified as a type of glycosaminoglycan; it is rich in sulfur and is related to glucosamine. Glycosaminoglycans affect how the body processes oxalate—a substance linked to kidney stones. In one study of forty people with a history of kidney stones, 30 mg twice a day of mixed glycosaminoglycans reduced urinary oxalate excretion in fifteen days—a change that could drop the risk of stone formation.10 However, while experts believe that glycosaminoglycans effectively prevent formation of kidney stones in test tube studies, effects in humans have been inconsistent.11

Where is it found? The only significant food source of chondroitin sulfate is animal cartilage.

Who is likely to be deficient? Because the body makes chondroitin, the possibility of a dietary deficiency remains uncertain. Nevertheless, chondroitin sulfate may be reduced in joint cartilage affected by osteoarthritis and possibly other forms of arthritis.

How much is usually taken? For atherosclerosis, researchers have sometimes started therapy using very high amounts, such as 5 grams twice per day with meals, lowering the amount to 500 mg three times per day after a few months. Before taking such high amounts, people should consult a nutritionally oriented doctor. For osteoarthritis, a typical level is 400 mg three times per day. The ability for chondroitin to be absorbed orally is still under question.

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The hypothesis that glucosamine sulfate and chondroitin sulfate work synergistically in the support of osteoarthritis remains unproven. The fact that they are structurally similar suggests that they may act in similar ways.

At the time of writing, there were no well-known drug interactions with chondroitin sulfate.
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References:
1. Moss M, Kruger GO, Reynolds DC. The effect of chondroitin sulfate on bone healing. Oral Surg Oral Med Oral Pathol 1965;20:795–801.
2. Kerzberg EM, Roldan EJA, Castelli G, Huberman ED. Combination of glycosaminoglycans and acetylsalicylic acid in knee osteoarthritis. Scand J Rheum 1987;16:377.
3. Rovetta G. Galactosaminoglycuronoglycan sulfate (Matrix) in therapy of tibiofibular osteoarthritis of the knee. Drugs Exptl Clin Res 1991;17:53–57.
4. Mazieres B, Loyau G, Menkes CJ, et al. Le chondroitine sulfate dans le traitement de la gonarthrose et de la coxarthrose. Rev Rhum Mal Steoartic 1992;59:466–72.
5. Izuka K, Murata K, Nakazawa K, et al. Effects of chondroitin sulfates on serum lipids and hexosamines in atherosclerotic patients: With special reference to thrombus formation time. Jpn Heart J 1968;9:453–60.
6. Morrison LM, Bajwa GS, Alfin-Slater RB, Ershoff BH. Prevention of vascular lesions by chondroitin sulfate A in the coronary artery and aorta of rats induced by a hypervitaminosis D, cholesterol-containing diet. Atherosclerosis 1972;16:105–18.
7. Morrison LM, Branwood AW, Ershoff BH, et al. The prevention of coronary arteriosclerotic heart disease with chondroitin sulfate A: Preliminary report. Exp Med Surg 1969;27:278–89.
8. Morrison LM, Enrick NL. Coronary heart disease: Reduction of death rate by chondroitin sulfate A. Angiology 1973;24:269–82.
9. Lenclud C, Chapelle P, van Mylem A, et al. Effects of chondroitin sulfate on snoring characteristics: a pilot study. Curr Ther Res 1998;59:234–43.
10. Baggio B, Gambaro G, Marchini F, et al. Correction of erythrocyte abnormalities in idiopathic calcium-oxalate nephrolithiasis and reduction of urinary oxalate by oral glycosaminoglycans. Lancet 1991;338:403–5.
11. Cao LC, Boevé ER, de Bruihn WC, et al. Glycosaminoglycans and semisynthetic sulfated polysaccharides: an overview of their potential application in treatment of patients with urolithiasis. Urology 1997;50:173–83 [review].

 
 
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