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DIABETES
Are You at Risk?

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bulletDiabetes & Syndrome X -  Are YOU at Risk?
Over 16,000,000 individuals have this incurable disease. Today, at least half of them don’t know they have it. Many millions more are at risk. Are you one of them?
 
BOSTON, MA–The American Diabetes Association announces that every 60 seconds, someone in the U.S. is diagnosed with diabetes. Currently, eight million diagnoses have been made while the federal government projects that yet another 8 million are undiagnosed.
 
The total number of people, 16 million, has increased by 5 million since 1983. All this is bad news. However, the worst news is that many people have the disease for 7-10 years before they have the diagnosis. This indicates as long as a decade of chronic high blood sugar damage to the body.
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Diabetes & Syndrome X
What exactly is Diabetes?
Natural Help
Do You Have It
Are you at Risk?
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bullet 
What exactly is diabetes?
Why are the numbers rising? How can so many people have it? How can so many be unaware that they have it? How can so many more be at risk? What are the risks? Are you at risk?
For many years, diabetes was called the "sugar disease." It is a disease in which the body either doesn’t produce insulin or doesn’t use it properly. Insulin is a hormone normally secreted by the pancreas. The presence of insulin is necessary for the cellular uptake of blood sugar (glucose), the body’s main energy source. While the cells are starved for fuel, high glucose levels cause irreversible damage to the blood vessels. Because of this, the person with diabetes is at far greater than average risk for blindness, kidney disease, nerve damage, heart disease, and stroke.
 
Although the end results are potentially the same, there are three common forms of diabetes: type 1, type 2, and gestational. Formerly known as IDDM (insulin dependent diabetes mellitus), type 1 continues to describe people who do not produce insulin. Of the two kinds of type 1, the predominant one is an autoimmune disorder in which the body destroys the insulin-producing cells of the pancreas (the beta cells). Typically, this occurs during childhood or adolescence. Also classified as type 1 are the rare forms of diabetes for which there are no scientific explanations.
 
Type 1 accounts for about 700,000 cases, about 5-10 percent of all diabetes. It is more common in Caucasian persons. In children, this type of diabetes may look like the flu. Other warning signs include:

Frequent urination

Unusual thirst

Extreme hunger

Unusual weight loss

Extreme fatigue

Irritability 

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Type 2 diabetes is the real bugaboo. Accounting for 90-95 percent of all cases, this disease is nearing epidemic proportions. People with type 2 diabetes continue to produce insulin. Called NIDDM (non-insulin dependent diabetes mellitus) for many years, that label was misleading because some people with type 2 do need to augment their own insulin supply. The underlying problem here is insulin resistance, a condition in which the cells have lost their sensitivity to insulin and no longer respond correctly to its presence. In many cases, the body floods the cells with insulin; in others, adequate insulin is not produced. In all cases, the cells resist insulin, leaving too much glucose circulating in the blood.
 
Although there are exceptions, type 2 typically occurs in people who are over 45, overweight, lead a sedentary life, and may have a family history of diabetes. Also, African American people, people of Mexican, Cuban, or Puerto Rican descent, and Native American people are at greater risk than people of predominately European ancestry. Native Americans are particularly susceptible to diabetes. Over 12 percent of the Native American population suffer from this disease, compared with slightly over five percent of the general population. Warning signs for type 2 are:

Any of the type 1 symptoms

Recurring skin, gum or bladder infections 

Blurred vision

Cuts/bruises that are slow to heal

Tingling/numbness in the hands or feet

Frequent infections

The third common form of diabetes is gestational diabetes which occurs only during pregnancy. It disappears after giving birth. However, it can predict type 2 diabetes in later life. Women who experience it are well-advised to take the preventive measures described in this newsletter. Women routinely screened for diabetes in their third trimester are: over 25 years old, overweight, and have either a family history or an ethnic proclivity for the disease.
 
A simple blood test is recommended for diagnosing diabetes. It is an eight hour fasting test called fasting plasma glucose (FPG). For many years, blood glucose at 140+ mg/dl (milligrams of glucose per deciliter of blood) was considered the cutpoint for a diabetes diagnosis. However, capillary damage was occurring at levels in the low to mid 120s. In 1997, the cutpoint was lowered to 126 mg/dl. With this more appropriate diagnosis, earlier steps can be taken to slow the progression of the disease and reduce the danger of its life-threatening complications. A label of impaired fasting glucose is assigned to those whose measurements register 110 to 125 mg/dl. This classification is an important yellow light since it is possible to have chronically high glucose levels and be totally free of symptoms for many years.
To identify those at risk, the ADA now recommends that everybody 45 and older be given the FPG every three years. If you are under 45 but at risk because of weight, activity level, and family or ethnic tendency, it is a good idea to start testing after 25 and be tested yearly. This admonition includes people who also have heart disease risk factors like high blood pressure, low HDLs, and high triglycerides.
 
bullet 
Syndrome X: Do You Have It?
Are you slowly gaining weight? Is it tough losing it? Is your blood pressure higher than you wish it were? How about your cholesterol levels? Do you feel tired after you eat? At other times when you shouldn’t? You could have Syndrome X. Syndrome X is the name of a group of six symptoms which are an accurate predictor of both heart disease and diabetes. The symptoms are insulin resistance, glucose intolerance, abnormally high insulin levels, high blood pressure, high triglycerides, and low HDLs (high density lipoproteins, "good" cholesterol). Coined by Gerald M. Reaven, M.D., of the Standford University Medical Center in 1988, Dr. Reaven theorized that insulin resistance could be a factor in obesity, high blood pressure, and heart disease. Until that time, researchers only considered insulin resistance in connection with type 2 diabetes. However, Syndrome X contributes to both obesity and heart disease whether or not there is a diagnosis of diabetes.  We now know that there is a one in four probability that any one of us will develop insulin resistance. This probability increases with the amount of refined carbohydrates (products made with white flour and/or with sugar) and fats (especially large amounts of polyunsaturated and saturated) we include in our usual food intake. This condition can be prevented, and even reversed, by following the guidelines for maintaining a healthy heart along with those for keeping your glucose levels steady throughout the day. In short, achieve and maintain a good weight, exercise regularly, and eat smaller, more frequent meals which include lots of fresh, whole foods.

If you have been given a diagnosis of diabetes, your most important goal is to keep your blood glucose as close to normal as possible. This is the only hope you have to alleviate the serious complications of the disease. In most cases of type 2, this can be achieved with diet and exercise. The ADA is currently advising a method called Carbohydrate Counting. They recommend this method be individualized by a registered dietician. Considering the plethora of current dietary advice and vastly differing opinions, this would seem like the easiest way to develop your food plan. If you know or suspect that you are insulin resistant, you might take the same advice. "The Zone" diet which discourages high blood glucose could also work well.

 
bulletAre You At Risk?

1. My weight is equal to or above that listed in the At-Risk Weight Chart, below.

Yes=5, No=O ___

2. I am under 65 and I get little or no exercise during a typical day.

Yes=5, No=O ___

3. I am between 45 and 64 years old. Yes=5, No=O ___
4. I am 65 or older. Yes=5, No=O ___
5. I have given birth to a baby weighing more than 9 pounds. Yes=5, No=O ___
6. I have a sister or a brother with diabetes. Yes=5, No=O ___
7. I have a parent with diabetes. Yes=5, No=O ___
  TOTAL: ___

            

 

Men / Women

     
4’9" 133 4’10" 137 4’11" 140 5’0" 143 5’1" 146 157 5’2" 150 160
5’3" 154 162 5’4" 147 165 5’5" 161 168 5’6" 164 172 5’7" 168 175 5’8" 172 179
5’9" 175 182 5’10" 178 186 5’11" 182 190 6’0" 194 6’1" 199 6’2" 203
6’3" 209          
 
Scoring: 3-9 points: Chances are you are at low risk for diabetes now. But you may be at higher risk in the future. Maintain a healthy weight and exercise regularly to keep risk low. 10 or more points: You are at high risk for diabetes. See your doctor to be tested.
This chart was developed by the American Diabetes Association.  For more information, call (800) DIABETES or visit www.diabetes.org.

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bulletNatural Help

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Sugar Control Supplements

Free Radicals Arrested: Harmful Activities Halted: Free radicals are natural and useful by-products in the body’s vital processes. Free radicals only cause damage when there are more than the body’s antioxidant systems can handle. People with diabetes are particularly susceptible to free radical damage. Glucose at levels consistently higher than 120 mg/dl actually auto-oxidizes. Of course, the body responds to the presence of glucose by releasing insulin, and insulin generates more free radicals. Adding insult to injury, the joining of glucose to protein in the formation of AGEs also causes free radical release. The body simply cannot keep up with all this oxidative stress.
Vitamin C and E supplementation is imperative. Besides defending against free radical damage, both of these vitamins have been shown to reduce protein glycosylation. Vitamin C is recommended at 1-2 grams daily. Since a daily dose of 400 IU of vitamin E has been shown to protect against heart disease by reducing the oxidation of LDLs (the "bad" cholesterol), certainly this is the minimum for an anti-diabetes regimen. Other helpful nutrients include a multivitamin-mineral formula (the B vitamins are critical to carbohydrate metabolism), additional calcium, and magnesium (often deficient in diabetes), a chromium supplement (lowers glucose and decreases glycosylation), vanadyl sulfate (a salt of vanadium which mimics the action of insulin) and Trim Plex (an naturalfractionated protein from White Kidney bean extract, help stable blood sugar levels).
Chromium is an essential trace element required for normal insulin functioning. Chromium deficiency produces diabetic symptoms including high blood sugar, impaired glucose metabolism, decreased insulin binding and receptor number, decreased HDL cholesterol, and increased total cholesterol and and triglycerides. A diet high in refined grains and sugars exacerbates Chromium depletion. Firstly, these foods contain low amounts of Chromium, yet Chromium is necessary to metabolize them. Secondly, a high consumption of sugars and refined starches foods increases Chromium excreted in the urine by 10 to 300%. Typical North American and European diets require more Chromium than they provide, thus leading to long-term depletion of Chromium from our bodies. The majority of the US population does not obtain the recommended intake of 50 to 200 micrograms per day. Brewer's yeast, beer, whole grains, cheese, liver, and meat can be good dietary sources of Chromium; however, Chromium contents of foods vary widely. Much of the Chromium in foods may be unabsorbable metal contamination from stainless steel food processing equipment. Refining of grains and sugars, and processing of foods removes most of the absorbable Chromium. The Chromium requirements of our Paleolithic ancestors were almost certainly lower than ours, since they consumed no cereal grains or refined sugars, but did consume lean protein, balanced PUFA, and plenty of soublesoluble fiber. They also lived in the geologically active East African Rift Valley for over for 4 million years. During this time, volcanoes erupted often, covering the area with trace-element rich lava and ash. Further, traditional hunting societies make a point to consume the internal organs of game, which are rich sources of absorbable trace elements, Chromium included. We have no reason to think this behavior differed in the past. Therefore it is considered that this relative lack of Chromium in Western diets is a major factor in the increasing incidence of NIDDM. Appropriate dietary choices and chromium supplementation of 200-400 micrograms per day may help prevent NIDDM, but may not be sufficient to reverse existing diabetes. A recent double-blind placebo-controlled study on 3 groups of 60 Chinese NIDDM found that 500 micrograms chromium picolinate given twice per day for 4 months was greatly superior to placebo, lowering fasting blood glucose (129 mg/dL vs 160 mg/dL), post-meal blood glucose, (190 mg/dL vs 223 mg/dL) and nearly normalizing "glycated hemoglobin" (6.6±0.1% vs 8.5±0.2%). Glycated hemoglobin is another test used to measure the extent of diabetes. When blood glucose is too high, glucose can chemically bond to hemoglobin in the blood, which reduces its ability to bind and carry oxygen. Total cholesterol and insulin levels also dropped. A third group given 100 micrograms twice per day showed lesser but significant improvements in glycated hemoglobin and insulin levels, but not blood glucose levels If you are taking any medication to control your blood sugar, start with 200 micrograms per day for a week, and monitor your glucose closely. Increase by 200 micrograms per week until you reach 1,000, and then have medication adjusted accordingly. For IDDM, use the same approach. Add Chromium in 100 to 200 microgram increments per week. Monitor glucose closely, because you should experience a decrease in your insulin requirements. If you have trouble adjusting the insulin dose you take just before going to bed, do not take Chromium supplements within 3 hours of retiring. Work up to the level of Chromium that allows you to consistently reduce your daytime insulin, and stabilize your requirements. Then work on the night dosage. Research
Flax Seed: People with type 2 or non-insulin dependent diabetes are 2-5 times more likely to develop heart disease than people without diabetes. They are also prone to high triglyceride (blood fat) levels, a heart disease risk factor. Flax Seed protect against heart disease. Research
Gymnena Sylvestre: The leaves of this climbing vine are an ancient Ayurvedic treatment for diabetes. Gymnena sylvestre appears to stimulate insulin secretion, and lower cholesterol and triacyglycerols without side effects. It has been shown to rejuvenate dysfunctional pancreatic cells in diabetic rats. In an open study in India, Gymnena was tested on 22 patients who were not insulin dependent but taking oral antidiabetic medications. The patients were given 400 mg of a standardized Gymnena extract per day for 18 to 20 months. They were all able to reduce their medication dosages, and 5 were able to discontinue their medications. The extract was judged superior to the medications for long-term blood sugar stabilization, lowering of triacyglycerols, and the overall well-being of the patients. In a sister controlled study, 400 mg of the extract was given to 27 insulin-dependent diabetics. Insulin requirements dropped by nearly 50%, and fasting blood sugar dropped also. Triacyglycerols dropped to near normal levels, and the subjects reported that their mood and physical performance improved. Since gurmar acts primarily to increase insulin secretion, it may not be appropriate for individuals with chronically high levels of circulating insulin. This would include most people with NIDDM, but nobody with IDDM. In fact, Gymnena is an herb which is probably targeted more towards those with IDDM than those with NIDDM. Gymnena does not seem to lower blood sugar levels in all people, and does take time to become effective, but the beneficial effects on triacyglycerols and cholesterol may make it worth trying no matter what. One capsule of a standardized extract can be taken 1 to 4 times per day. Those with IDDM or on diabetic medications should start with 1 capsule per day and increase by 1 capsule per week, monitoring blood sugar closely. Research
Korean Ginseng (Panax ginseng) Traditional Chinese medicine recognized that ginseng helped diabetes centuries ago. On the Western side of the globe, a landmark 1995 Finnish study found that only 200 mg ginseng per day for 8 weeks improved mood and physical activity, and lowered fasting blood glucose and body weight compared to placebo. This is only a very small ginseng dosage, and I'm frankly surprised it has this much effect. A dosage considered safe and perhaps more appropriate would be 200 mg ginseng extract or 500 mg capsules, 2 to 4 per day. Those with IDDM or on diabetic medications should start with 1 capsule and increase by 1 capsule per week, monitoring blood sugar closely, however dramatic changes in glucose should not be expected. Excessive amounts of Korean ginseng may cause elevated blood pressure, so you should check your blood pressure periodically while increasing your dosage. Research
 
bulletALA: Absolutely Amazing Metabolic Substance Brings Help, Increases Health
In a recent study, the blood sugar levels of diabetic participants were normalized by taking 600 mg daily of alpha lipoic acid (or lipoic acid) supplements. Blood tests showed increased insulin activity, more insulin sensitivity, and greater glucose tolerance. This sugar-regulating property of lipoic acid has made it a successful treatment for diabetes in Europe for over 30 years. Further, it protects against the terrific free radical threat of diabetes, and limits glycation  Plus it reduces nerve pain and damage and improves nerve function. Lipoic acid is a natural substance found in all living things. It works in the cells as a metabolic coenzyme, essential to energy production. Relative to diabetes, it helps to move glucose into the cells independently of insulin. This helps to lower circulating glucose levels and to enhance energy levels. Normally, the body does not depend on lipoic acid as an antioxidant. However, the supplement form gives the cells lipoic acid to spare. Under these conditions, not only are its energy-producing capacities enhanced, its antioxidant properties rise to stellar heights. Research
Lipoic acid is a truly spectacular antioxidant. It has been called a "broad spectrum" antioxidant, a "wild card" antioxidant, and a "universal" antioxidant. It meets all six of renowned researcher Lester Packer’s criteria for being the antioxidant’s antioxidant: 1) neutralizes free radicals; 2) is absorbed and utilized rapidly and easily; 3) is highly concentrated in cells, tissues, and extracellular fluid; 4) is capable of enhancing the effects of other antioxidant; 5) chelates free metal ions (these are the toxic pollutants we take in from our environment); and 6) promotes normal gene expression. (The lipoic acid molecule is so small it can penetrate the cell nucleus and protect DNA.). The greatest free radical activity occurs as a natural result of cellular energy production. (Glucose itself is an oxidative substance. See "Free Radicals Arrested," this issue.) Lipoic acid is able to quench free radicals right at the source of cellular energy production, the mitochondria (the powerhouses of the cells). Further, it has the capacity to protect both water- and lipid- (fat) based substances in free radical interactions. Because of this dual affinity, it helps to recycle used vitamin C and E so that they can continue to give their antioxidant support to the body.
Nerve damage is one of the most devastating complications of diabetes, affecting 60-70 percent of those stricken with the disease. People with diabetic neuropathy are five times more likely to die early than diabetics with healthy nervous systems. This is because nerve damage leads to heart disease, poor wound healing, infection, impotency, and numbness of the limbs. At its extreme, nerve damage can lead to lower limb amputation. (Each year, 54,000 individuals lose a foot or leg to diabetes.) In addition, neuropathy is very painful.
The good news is that lipoic acid shows promise for stopping and possibly reversing nerve damage. A four month German study resulted in a modest but significant improvement in sympathetic nervous system function. In this study, the nerves affecting heart rhythm were observed. During the usual course of the disease, these nerves eventually lose their protective outer covering (the myelin sheath) and deteriorate. Heart rate variability in the lipoic acid group was statistically improved over the controls. Participants took 800 mg daily.
In his Lipoic Acid: Metabolic Antioxidant, well-known biochemist Richard Passwater, PhD, reports that researchers have induced the regenerative growth of new nerve fibers using lipoic acid. In addition, he writes, "In as little as three weeks there is a significant reduction in pain and numbness....[with] no adverse effects [using 600 mg per day]."  There is little doubt that those with diabetes should support their bodies with lipoic acid. Plus, the peripheral nervous system gains support when lipoic acid is taken with vitamin B5, pantothenic acid. Incidentally, lipoic acid is the second nutritional supplement to demonstrate relief of neuropathy. The first was gamma linolenic acid (GLA). This essential fatty acid is found in evening primrose, borage, and black currant oils. In general, people with diabetes convert fatty acids inefficiently and frequently find GLA helpful. Other helpful oils are fish oils (EPA or broiled deep ocean filets) and monounsaturated fats (canola, olive, and macadamia oils), both of which are effective in lowering glucose levels.
 
bulletOne more thing to swallow, and a bitter pill for many, is exercise.
Among its many benefits, moderate exercise improves insulin sensitivity. If you don’t have diabetes, just 30 minutes a day of exercise such as brisk walking greatly reduces the risk of ever developing it. Positive changes in diet, an increase in exercise, and some supplements can cause a significant lowering of blood sugar levels. If you have diabetes, it is a good idea to invite the support of your health practitioner as you make these changes.
Also see 
Diabetic and Lifestyle Introduction to Diabetic Dietary Supplements
Natural Help New Hope for Diabetics
Control Diabetes Naturally
Ask the Expert about Diabetes Supplements (click)
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