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Psyllium
(Plantago ovata, Plantago ispaghula)

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Common names: Plantago seed

Part used and where grown: Psyllium is native to Iran and India and is currently cultivated in these countries. The seeds are used.

On This Page
Historical or traditional use
Recent findings
Do scientists know how it works?
Types of products
Safety
Historical or traditional use
In addition to its traditional and current use for constipation, psyllium was also used topically to treat skin irritations, including poison ivy reactions and insect bites and stings. It has also been used in traditional herbal systems of China and India to treat diarrhea, hemorrhoids, bladder problems, and high blood pressure.

Psyllium Seed

Active constituents: Psyllium is a bulk-forming laxative and is high in both fiber and mucilage. Psyllium seeds contain 10-30% mucilage. The laxative properties of psyllium are due to the swelling of the husk when it comes in contact with water. This forms a gelatinous mass and keeps the feces hydrated and soft. The resulting bulk stimulates a reflex contraction of the walls of the bowel, followed by emptying.1lll

Psyllium, also known as fleawort and fleaseed, because the seeds look like fleas, is derived from the seed coats or husks of various plantain plants, especially those native to the Indian subcontinent, the Middle East, and northern Africa. The leaves of related North American plantain species (Plantago major, P. lanceolata), are important first-aid herbs (see plantain). Psyllium is the primary ingredient in many bulk-producing, nonirritant laxatives, which are milder and much safer treatments for constipation than stimulant laxative herbs such as senna and cascara sagrada. Due to the concerns about regular bowel function while in space, John Glenn and a fellow astronaut took a commercial psyllium product, Metamucil, with them on their nine-day flight aboard the space shuttle Discovery in 1998.

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Traditional uses
Seeds of plantago species have long been used by Chinese and Ayurvedic herbalists to regulate bowel movements and alleviate diarrhea and constipation. Herbalists use psyllium to help treat intestinal conditions such as colitis and dysentery, bladder problems, rheumatism, ulcers, and urinary tract infections. Psyllium was traditionally used in some cough remedies and is still used topically for the treatment of hemorrhoids, skin rashes, and insect bites and stings.

 

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Modern uses
In recent years Psyllium has become one of the world's most-used herbs. It is almost universally recognized as a premier source of dietary fiber, a useful substance to regulate the bowels, and a safe and effective constipation and diarrhea remedy. It can aid in the treatment of obesity and overeating by instilling a sense of fullness. Studies suggest that psyllium may lower blood cholesterol levels and blood pressure, thus helping to prevent heart disease. It may suppress blood sugar fluctuation and play a role in the treatment of hypoglycemia and diabetes. Psyllium may also be useful in preventing or treating:
hemorrhoids irritable bowel syndrome diverticular disease

Recent findings In a triple-blind study (one in which not only subjects and researchers are kept blind, but statisticians as well) of "non-restrained eaters," a psyllium-based supplement was shown to cause a significant increase in the subjective feeling of fullness and a reduction in the consumption of fat and calories. The researchers concluded that psyllium could be useful in weight control diets.

bulletA clinical trial of a plantain-flour based solution found that it was an effective treatment for dehydration due to acute diarrheal diseases.
bulletIn a multi-center clinical trial, researchers determined that psyllium supplements might be as effective as mesalamine, a prescription anti-inflammatory drug, for maintaining remission in ulcerative colitis, a serious intestinal disorder.
bulletPsyllium decreased by about one-third the absorption of a synthetic estrogen administered at the same time to rabbits.
bulletSpanish researchers found that psyllium increased the frequency of stools among patients with chronic constipation with or without irritable bowel syndrome.
bulletIn a study done on fifty patients in 1996, a commercial psyllium product significantly reduced the number of bleeding episodes among patients with internally bleeding hemorrhoids.

Do scientists know how it works?
Psyllium is a source of both soluble and insoluble dietary fiber, though it is mostly soluble. The seed husks are rich in the gelatinous, water-absorbing substance mucilage. Mucilage is not broken down by enzymes in the digestive tract, nor is it absorbed. Rather, in contact with water it swells and forms a gel. In cases of diarrhea, mucilage absorbs excess water and slows bowel transit time. In cases of constipation, mucilage adds bulk to stools, stimulates the walls of the bowels to contract, and thus speeds bowel transit time.
Psyllium's regulation of blood cholesterol and blood sugar levels may be due to effects on cholesterol-containing bile and the digestion of carbohydrates.

How much should I take? Many people take 7.5 grams of the seeds or 5 grams of the husks one to two times per day, with water or juice. It’s important to maintain adequate fluid intake when using psyllium.

Are there any side effects or interactions? Using psyllium in recommended amounts is generally safe. People with chronic constipation should seek the advice of a health care professional. Side effects, such as allergic skin and respiratory reactions to psyllium dust, have largely been limited to people working in plants manufacturing psyllium products.

Types of products
Psyllium is sold in powders and capsules. It is sometimes combined with digestive regulators such as bifidus. It is also available in formulas and combination products for detoxification, colon health, and constipation.

Safety
Psyllium is considered safe and nontoxic when used properly. A few people may experience flatulence or upset stomach when taking psyllium. Always drink plenty of water with psyllium to promote its therapeutic effects and to prevent it from causing choking or intestinal blockage. Psyllium shouldn't be used by anyone with any kind of bowel narrowing or obstruction. Avoid psyllium during pregnancy. A very few people may develop allergic reactions to psyllium, although this problem is more common among workers in the psyllium industry exposed to it much more extensively. Taking psyllium at the same time as medications can delay or decrease the latter's absorption.
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References
Arias, M.M., et al., "Oral rehydration with a plantain flour-based solution in children dehydrated by acute diarrhea: a clinical trial," Acta Paediatr (1997), 86(10):1047-51
Fernandez, N., et al., "Influence of two commercial fibers in the pharmacokinetics of ethinylestradiol in rabbits," J Pharmacol Exp Ther (1998), 286(2):870-74
Fernandez-Banares, F., et al., "Randomized clinical trial of Plantago ovata seeds (dietary fiber) as compared with mesalamine in maintaining remission in ulcerative colitis. Spanish Group for the Study of Crohn's Disease and Ulcerative Colitis (GETECCU)," Am J Gastroenterol (1999), 94(2):427-33
Perez-Miranda, M., et al., "Effect of fiber supplements on internal bleeding hemorrhoids," Hepatogastroenterology (1996), 43(12):1504-07
Voderholzer, W.A., et al., "Clinical response to dietary fiber treatment of chronic constipation," Am J Gastroenterol (1997), 92(1):95-98

Abstracts
Title: Randomized clinical trial of Plantago ovata seeds (dietary fiber) as compared with mesalamine in maintaining remission in ulcerative colitis. Spanish Group for the Study of Crohn's Disease and Ulcerative Colitis (GETECCU)
Author: Fernandez-Banares F; Hinojosa J; Sanchez-Lombra~na JL; Navarro E; Martinez-Salmeron JF; Garcia-Puges A; Gonzalez-Huix F; Riera J; Gonzalez-Lara V; Dominguez-Abascal F; Gine JJ; Moles J; Gomollon F; Gassull MA Source: Am J Gastroenterol, 94(2):427-33 1999 Feb
Abstract: OBJECTIVE: Butyrate enemas may be effective in the treatment of active distal ulcerative colitis. Because colonic fermentation of Plantago ovata seeds (dietary fiber) yields butyrate, the aim of this study was to assess the efficacy and safety of Plantago ovata seeds as compared with mesalamine in maintaining remission in ulcerative colitis. METHODS: An open label, parallel-group, multicenter, randomized clinical trial was conducted. A total of 105 patients with ulcerative colitis who were in remission were randomized into groups to receive oral treatment with Plantago ovata seeds (10 g b.i.d.), mesalamine (500 mg t.i.d.), and Plantago ovata seeds plus mesalamine at the same doses. The primary efficacy outcome was maintenance of remission for 12 months. RESULTS: Of the 105 patients, 102 were included in the final analysis. After 12 months, treatment failure rate was 40% (14 of 35 patients) in the Plantago ovata seed group, 35% (13 of 37) in the mesalamine group, and 30% (nine of 30) in the Plantago ovata plus mesalamine group. Probability of continued remission was similar (Mantel-Cox test, p = 0.67; intent-to-treat analysis). Therapy effects remained unchanged after adjusting for potential confounding variables with a Cox's proportional hazards survival analysis. Three patients were withdrawn because of the development of adverse events consisting of constipation and/or flatulence (Plantago ovata seed group = 1 and Plantago ovata seed plus mesalamine group = 2). A significant increase in fecal butyrate levels (p = 0.018) was observed after Plantago ovata seed administration. CONCLUSIONS: Plantago ovata seeds (dietary fiber) might be as effective as mesalamine to maintain remission in ulcerative colitis.
Language: Eng
Unique Identifier: 99145239
MESH Headings: Adult; Anti-Inflammatory Agents, Non-Steroidal *TU ANTIINFLAMMATORY AGENTS NONSTEROIDAL; Cathartics TU; Colitis, Ulcerative DH/DT/*TH; Dietary Fiber *TU; Fatty Acids, Volatile ME; Female; Human; Male; Mesalamine *TU; Middle Age; Plantago; Proportional Hazards Models; Psyllium *TU; Treatment Outcome
Publication Type: CLINICAL TRIAL; JOURNAL ARTICLE; MULTICENTER STUDY; RANDOMIZED CONTROLLED TRIAL
ISSN: 0002-9270
Country of Publication: UNITED STATES

These statements have not been evaluated by the Food and Drug Administration. This web site is not intended to diagnose, treat, cure, or prevent any disease. 
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