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Rosemary is a strong smelling herb and essential oil made from the thin leaves of a small evergreen shrub native to the Mediterranean. The ancient Egyptians and Greeks regarded it as a sacred plant and it has come to be associated with love, death, and remembrance. "There's Rosemary, that's for remembrance: pray, love, remember," Ophelia says in Hamlet. Rosemary was also a remedy for conditions ranging from stomach ache to nervous exhaustion. It remains a popular herb today for these and a variety of other medical conditions, as well as a useful culinary spice and garden ornamental.
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| Recent findings |
| Spanish researchers who tested the essential oil of rosemary, as well as those derived from lemon balm and lavender, for their actions against bacteria, fungi, and yeasts found that all three oils countered the microorganisms tested. |
| A rosemary leaf extract influences the metabolism and action of estrogen hormones, according to an animal study conducted by researchers at Rutgers University in 1998. |
| A Jordanian researcher determined that rosemary essential oil has a relaxant effect on the smooth muscles of the trachea in rabbits. |
| A number of recent studies have focused on apparent antioxidant and anti-tumor properties of the herb. For example, a 1995 study found that four diterpene compounds in rosemary effectively protected against lipid peroxidation of fats. Another study published in the same year concluded that constituents of rosemary were promising candidates for chemopreventive programs because of their ability to detoxify an important human carcinogen. |
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| conditioners, body lotions, shampoos, soaps, and hair oils |
| formulas for digestion, stomach and nausea, brain and memory, and circulation |
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Abstracts
Title: Rosemary components inhibit
benzo[a]pyrene-induced genotoxicity in human bronchial cells
Author: Offord EA; Mace K; Ruffieux C; Malnoe A; Pfeifer AM
Address: Nestle Research Centre, Lausanne, Switzerland
Source: Carcinogenesis, 16(9):2057-62 1995 Sep ,br> Abstract: The commonly used spice
and flavouring agent, rosemary, derived from the leaves of the plant Rosmarinus
officinalis L., displays antioxidant properties in foods and in biological systems.
Moreover, in animal models rosemary components were found to inhibit the initiation and
tumour promotion phases of carcinogenesis. In this work, we studied the mechanisms by
which rosemary components block initiation of carcinogenesis by the procarcinogen
benzo[a]pyrene (B[a]P) in human bronchial epithelial cells (BEAS-2B). Whole rosemary
extract (6 micrograms/ml) or an equivalent concentration of its most potent antioxidant
constituents, carnosol or carnosic acid, inhibited DNA adduct formation by 80% after 6 h
co-incubation with 1.5 muM B[a]P. Under similar conditions, cytochrome P450 (CYP) 1A1 mRNA
expression was 50% lower in the presence of rosemary components, and CYP1A1 activity was
inhibited 70-90%. The observed reduction of DNA adduct formation by rosemary components
may mostly result from the inhibition of the activation of benzo[a]pyrene to its ultimate
metabolites. Carnosol also affected expression of the phase II enzyme
glutathione-S-transferase which is known to detoxify the proximate carcinogenic metabolite
of B[a]P. Treatment of BEAS-2B cells with carnosol (1 microgram/ml) for 24 h resulted in a
3- to 4-fold induction of GST pi mRNA. Moreover, expression of a second important phase II
enzyme, NAD(P)H: quinone reductase, was induced by carnosol in parallel with GST pi.
Therefore, rosemary components have the potential to decrease activation and increase
detoxification of an important human carcinogen, identifying them as promising candidates
for chemopreventive programs.
Language: Eng
Unique Identifier: 96018698
MESH Headings: Anticarcinogenic Agents *TU; Benzo(a)pyrene *AI/*TO BENZOPYRENE A; Bronchi
*DE/EN/ME; Bronchial Neoplasms CI/PC; Carcinogens *TO; Cells, Cultured; Cytochrome P-450
AI/GE CYTOCHROME P 450; Drug Screening Assays, Antitumor; DNA Adducts *BI/DE; Enzyme
Induction; Enzyme Inhibitors TU; Glutathione Transferase BI; Herbs CH; Human; Isoenzymes
AI/GE; Mutagens *TO; Plant Extracts *TU; RNA, Messenger GE/ME
Publication Type: JOURNAL ARTICLE
ISSN: 0143-3334
Country of Publication: ENGLAND
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