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Beta Sitosterol
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  •  
    What does it do?
Beta-sitosterol—alone and in combination with similar plant sterols—reduces blood levels of cholesterol.1 2 This appears to be because beta-sitosterol blocks absorption of cholesterol.3 It has also been effective in reducing symptoms of benign prostatic hyperplasia.4

Although molecules quite similar to beta-sitosterol inhibit cancer cells in test tubes, the relevance of this information for people remains unknown.5

  •  
    Where is it found?
Beta-sitosterol is one of several plant sterols (cholesterol is the main animal sterol) found in almost all plants; high levels are found in rice bran, wheat germ, corn oils, and soybeans.
 
  •  
    Who is likely to be deficient?
Because beta-sitosterol is not an essential nutrient, deficiencies do not occur.

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  • How much is usually taken?
From 500 mg up to 10 grams of beta-sitosterol has been used each day for reduction of elevated blood cholesterol in clinical research. Between 60 (20 mg three times per day) and 130 mg per day have been used in trials successfully reporting a reduction in prostatic hyperplasia-related symptoms.6 7
 
  •  
    Are there any side effects or interactions?
No significant side effects or interactions have yet been reported in studies on beta-sitosterol.

At the time of writing, there were no well-known drug interactions with beta-sitosterol.

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References:
1. Lees AM, Mok HYI, Lee RS, et al. Plant sterols as cholesterol-lowering agents: Clinical trials in patients with hypercholesterolemia and studies of sterol balance. Atheroscler 1977;28:325–38.
2. Pelletier X, Belbraouet S, Mirabel D, et al. A diet moderately enriched in phytosterols lowers plasma cholesterol concentrations in normocholesterolemic humans. Ann Nutr Metab 1995;39:291–95.
3. Grundy SM, Ahrens EH Jr, Davignon J. The interaction of cholesterol absorption and cholesterol synthesis in man. J Lipid Res 1969;10:304–15 [review].
4. Berges RR, Windeler J, Trampisch HJ, et al. Randomised, placebo-controlled, double-blind clinical trial of beta-sitosterol in patients with benign prostatic hyperplasia. Lancet 1995;345:1529–32.
5. Kiriakdis S, Stathi S, Jha HC, et al. Fatty acid esters of sitosterol 3ß-glucoside from soybeans and tempeh (fermented soybeans) as antiproliferative substances. J Clin Biochem Nutr 1997;22:139–47.
6. Berges RR, Windeler J, Trampisch HJ, et al. Randomised, placebo-controlled, double-blind clinical trial of beta-sitosterol in patients with benign prostatic hyperplasia. Lancet 1995;345:1529–32.
7. Klippel KF, Hiltl DM, Schipp B. A multicentric, placebo-controlled, double-blind clinical trial of ß-sitosterol (phytosterol) for the treatment of benign prostatic hyperplasia. Br J Urol 1997;80:427–32.
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