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Also known as: CLA

What does it do? Conjugated linoleic acid (CLA) is a slightly altered form of the essential fatty acid linoleic acid. Preliminary animal and test tube research suggests that CLA might reduce the risk of cancers at several sites, including breast, prostate, colorectal, lung, skin, and stomach.1 2 3 4 Whether CLA will have a similar protective effect for people has yet to be demonstrated in human research.

Animal research also suggests an effect of CLA supplementation on reducing body fat,5 6 limiting food allergy reactions,7 preventing atherosclerosis,8 9 and improving glucose tolerance.10   Studies also shown reduces body fat and improves lean muscle mass/tone in every species that has been studied.  Its effects are well-documented by studies from University of Wisconsin. Researchers   there, looking for compounds that would stop cancer formation, found that CLA required less food and obtained equal body mass with lower body fat than controls.

Where is it found? CLA is found mainly in dairy products and also in beef, poultry, eggs, and corn oil. Bacteria that live in the intestine of humans can produce CLA from linoleic acid, but supplementation of a rich source of linoleic acid did not produce increases in blood levels of CLA in one human study.11 CLA is available as a supplement.

Product Recommendations

CLA is a naturally occurring free fatty acid that has been shown to improve nutrient usage and promote muscle tone. Each softgel contains: 1000.Conjugated Linoleic Acid, 430 mg Fatty Acid Complex

Who is likely to be deficient? No deficiencies of CLA are reported or believed to occur, since it is not an essential nutrient.

How much is usually taken? Animal research uses very large amounts, equivalent to several grams per day for humans. Until human research is conducted with CLA , the appropriate amount to take of this nutrient remains unclear.
Are there any side effects or interactions? The side effects of CLA are unknown, due to the limited research in humans. However, one unpublished human trial reported isolated cases of gastrointestinal upset.12  CLA part 2  Click here for Weight Loss and CLA Natural Diuretic Supplements
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References:
1. Cesano A, Visonneau S, Scimeca JA, et al. Opposite effects of linoleic acid and conjugated linoleic acid on human prostatic cancer in SCID mice. Anticancer Res 1998;18(3A):1429–34.
2. Thompson H, Zhu Z, Banni S, et al. Morphological and biochemical status of the mammary gland as influenced by conjugated linoleic acid: implication for a reduction in mammary cancer risk. Cancer Res 1997;57:5067–72.
3. Ip C. Review of the effects of trans fatty acids, oleic acid, n-3 polyunsaturated fatty acids, and conjugated linoleic acid on mammary carcinogenesis in animals. Am J Clin Nutr 1997;66(suppl):1523S–29S [review].
4. Parodi PW. Cows' milk fat components as potential anticarcinogenic agents. J Nutr 1997;127:1055–60 [review].
5. West DB, Delany JP, Camet PM, et al. Effects of conjugated linoleic acid on body fat and energy metabolism in the mouse. Am J Physiol 1998;275:R667–72.
6. Park Y, Albright KJ, Liu W, et al. Effect of conjugated linoleic acid on body composition in mice. Lipids 1997;32:853–58.
7. Sugano M, Tsujita A, Yamasaki M, et al. Conjugated linoleic acid modulates tissue levels of chemical mediators and immunoglobulins in rats. Lipids 1998;33:521–27.
8. Nicolosi RJ, Rogers EJ, Kritchevsky D, et al. Dietary conjugated linoleic acid reduces plasma lipoproteins and early aortic atherosclerosis in hypercholesterolemic hamsters. Artery 1997;22:266–77.
9. Lee KN, Kritchevsky D, Pariza MW, et al. Conjugated linoleic acid and atherosclerosis in rabbits. Atherosclerosis 1994;108:19–25.
10. Houseknecht KL, Vanden Heuvel JP, Moya-Camarena SY, et al. Dietary conjugated linoleic acid normalizes impaired glucose tolerance in the Zucker diabetic fatty fa/fa rat. Biochem Biophys Res Commun 1998;244:678–82.
11. Herbel BK, McGuire MK, McGuire MA, et al. Safflower oil consumption does not increase plasma conjugated linoleic acid concentrations in humans. Am J Clin Nutr 1998;67:332–37.
12. Thom E. A pilot study with the aim of studying the efficacy and tolerability of Tonalin CLA on the body composition in humans. Medstat Research Ltd., Lillestrom, Norway, July 1997[unpublished].
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  • CLA apparently inhibits at least two enzymes. One enzyme breaks down fat in the blood and the other breaks down fat stored in fat cells. The end result is a reduction in fat deposits and increased use of fat reserves for energy

  •  ALC plays a vital role in the metabolism of fats to energy. Also is great for replenishing energy post workout.

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