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- Theory
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- Because synephrine is a stimulant, similar to
caffeine and ephedrine, it is thought to have similar effects in terms of providing an
energy boost, suppressing appetite and increasing metabolic rate and caloric expenditure.
In traditional Chinese medicine (TCM), zhi shi is used to help stimulate the Qi (energy
force). Although synephrine and several other compounds found in zhi shi are structurally
similar to ephedrine and are known to act as stimulants (via adrenergic activity), zhi shi
does not appear to have the same negative central nervous effects of ma
huang (ephedra). Through its stimulation of specific adrenergic receptors (beta-3,
but not beta-1, beta-2 or alpha-1), zhi shi is theorized to stimulate fat metabolism
without the negative cardiovascular side effects experienced by some people with Ma Huang. (which stimulates all beta-adrenergic
receptors).
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- Scientific Support
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- The effects of synephrine alone or in combination
with other ingredients such as kola nut and guarana (both are caffeine sources) or with
salicylates such as white willow (a natural form of aspirin) generally fall into the
category of acting as a mild stimulant. The extract of citrus aurantium, in
addition to synephrine, also contains tyramine and octopamine. Octopamine may be related
in some way to appetite control, as it is thought to influence insect behavior by stopping
bugs from eating the citrus fruit (so if you’re an insect, this may be the perfect
weight loss supplement for you). Importantly, each of these related compounds (synephrine,
ephedrine and octopamine) can result in elevated blood pressure.
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A recent study conducted in dogs suggests that
synephrine and octopamine can increase metabolic rate in a specific type of fat tissue
known as brown adipose tissue (BAT). This effect would be expected to increase fat loss in
humans – except for one small details – adult humans don’t have brown
adipose tissue.
As it stands now, citrus aurantium extract exists as
one of the most over-hyped ingredients on the weight loss scene. There are some
interesting theories on how it might work to increase metabolic rate and promote
weight loss, but most are couched in pseudo-scientific mumbo jumbo and none are backed by
any credible scientific evidence of effectiveness in humans.
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Product Recommendations |
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- Thermogenic Formula with Zhi Shi extract,
Kola Nut, Chromium and HCA
- Special buy one get one FREE
- $12.99
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Synephrine the standardized ingredient in Bitter Orange has been the focus
of studies because of it's thermogenic properties. 2 tablets provides 900 mg Bitter
Orange, dried extract, 188 IU Vitamin A, retinol, 1.4 mg palmitate Vitamin C.
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