FURY Extreme (Pre-Workout) by Core Nutritionals (code 20off)

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Serving Size: 1 scoop (16.2 grams)
Servings Per Container: 28
Amount Per Serving %DV **
Creatine Monohydrate5,000 mg**
L-Citrulline3,000 mg**
Trimethylglycine (Betaine)2,500 mg**
Agmatine Sulfate1,000 mg**
N-Acetyl-Tyrosine750 mg**
Choline Bitartrate500 mg**
1,3,7-trimethylxanthine (Caffeine)300 mg**
L-Theanine200 mg**
PURENERGY® (Pterostilbene-Caffeine)100 mg**
Theobromine (3,7-dimethyl-1H-purine-2,6-dione) 99%100 mg**
Advantra-Z® Bitter Orange Extract (Citrus aurantium) (fruit) (50% synephrine)50 mg**
Hordenine (N,N-dimethyltyramine) HCl50 mg**
** Daily Value (DV) not established.
OTHER INGREDIENTS:
Citric Acid, Natural and Artificial Flavors, Silica, Calcium Silicate, Sucralose, Sodium Gluconate, Acesulfame Potassium


Directions For FURY Extreme: Mix 1 scoop with 8-16 ounces of water and consume approximately 15 minutes prior to your workout. For enhanced performance, stack with 1 serving of Core ABC and 1 serving of Core PUMP.

Warnings: This product is only intended for use in healthy adults 18 years of age or older. Pregnant or nursing women should not use this product. Consult your healthcare provider before using this product, especially if you are taking any prescription, over the counter medication, dietary supplement product , or if you have any pre-existing medical condition including but not limited to: high or low blood pressure, cardiac arrhythmia, stroke, heart, liver, kidney or thyroid disease, seizure disorder, psychiatric disease, diabetes, difficulty urinating due to prostate enlargement or if you are taking a MAOI (Monoamine Oxidase Inhibitor) or any other medication. Discontinue use and consult your health care professional if you experience adverse reaction to this product. Do not exceed recommended serving. Do not use in combination with caffeine or any stimulants, including but not limited to, coffee, tea, soda, and other dietary supplements or medications. Do not use under extreme conditions of heat, sleep deprivation, extreme cardiovascular exertion or dehydration. Do not combine with alcohol. Do not use if safety seal is broken or missing. Keep out of reach of children.

Extreme Pre-workout Performance Enhancer 

Everything You Need In A Pre-workout Powder, Proprietary Blends Not Included

Extreme Pre-Workout Performance Amplifier

When we first released Core FURY, we said a few things: we said that it was revolutionary, because it didn’t try to be. We said that it was formulated with clinically researched serving sizes, in a non-proprietary blend, that was made to be our most effective pre-workout supplement. We said it was amazing. We said that it couldn’t be topped. Well, we were wrong. 

With Core FURY Extreme, we have somehow improved on our best, most-potent, most-concentrated pre-workout by including even more science-backed ingredients, in even bigger servings. Best of all? We have crammed every last milligram of PR-smashing Core FURY Extreme goodness into a single scoop. 

No more debates about two scoops or three. Actually, no more debates period. Core FURY Extreme has every conceivable angle, mechanism, or benefit you’d want in a pre-workout covered, and we somehow managed to combine that with an amazing taste? An actual serving of creatine, one that would be enough for a creatine-only product? Yeah, we have that. One of the highest servings of citrulline, betaine, and agmatine out there? That too. What about an insane stimulant mixture, including a longer-lasting, more effective, clinically-studied form of caffeine in combination with pterostilbene? Of course. 

What Core FURY Extreme doesn’t have is room for error, or a proprietary blend that masks the amount of every ingredient. This product was made by the best, for the best, to be used as a single scoop, single product arsenal against fatigue and excuses. You want the scoop? You can’t handle the scoop. 

Scientific breakdown:

Creatine monohydrate: Sometimes called the “grandfather” of dietary supplements, creatine is, along with caffeine, one of the most extensively studied dietary compounds. Certainly, it is the most well-studied ergogenic aid. Generally speaking, the extensive amount of data on creatine demonstrates that it positively contributes to dilation of the vasculature, plasma-nutrient mobilization, post-workout nitrogen retention and protein synthesis, along with dose-dependently increasing contractile force through ATP (adenosine triphosphate) provision (i.e., it helps support increased strength).*

L-Citrulline: Citrulline is a non-essential, non-protein amino acid that forms during the urea cycle and forms ornithine when combined with carbon dioxide. Citrulline is also a critical source of endogenous (natural) arginine, as it is rapidly and efficiently converted to arginine in the vascular endothelium and other tissues. 

Like agmatine, the other arginine pre-cursor/byproduct featured in Core FURY Extreme, citrulline’s benefits have been shown to be greater than its parent compound. While arginine undergoes direct hepatic (liver) metabolism through the enzyme arginase, citrulline bypasses hepatic metabolism entirely and it is delivered straight to the bloodstream. The result is that gut absorption and plasma (blood) bioavailability studies comparing citrulline and arginine have shown two things. First, that citrulline is less readily destroyed and has greater absorption than arginine. Second, that citrulline supplementation increases arginine levels more effectively than arginine supplementation itself. 

Trimethylglycine (Betaine): Betaine (trimethylglycine) is found naturally in most living organisms. It is well known to protect non-mammalian animal life in conditions of osmotic stress (a rapid change in the amount of solute surrounding a cell), in addition to functioning as an osmolyte in mammalian (including human) tissues). Betaine is formed in cells as an oxidation product of choline and can be obtained in the diet from foods such as spinach and beets.

Agmatine sulfate: Agmatine is part of a group of compounds known as polyamines, alphatic amines which play multiple physiological roles in tissue growth and differentiation, body weight increment, brain organization, molecular mechanisms of hormonal action, intracellular signaling, and extracellular communication. Agmatine itself is naturally produced in the body by the breakdown of arginine. Paradoxically, the studied effects of agmatine not only appear to mimic those of its parent compound arginine, but in many cases, surpass it. These effects include an increase in localized bloodflow (better plasma delivery), dilation of the vasculature (expanding of blood vessels), increased nutrient delivery, and a hypothesized support for the health of the hypothalamic-pituitary axis.*

The literature suggests that agmatine sulfate’s positive regulation of NO (nitric oxide) levels occur within the classical NO-eNOS (endothelial nitric oxide synthase) pathway. Like arginine, agmatine appears to increase plasma nitric oxide via functioning as a competitive inhibitor of nitric oxide synthase. As a polyamine, agmatine may also play a role in the functioning of the hypothalamic-pituitary axis (HPTA). Data in mammals have shown that polyamines are related to gonadotropin release, and in particular, promote an increased luteinizing hormone (LH) production. This positive regulation of gonadotropin is suggested to be the result of increased γ-aminobutyric acid (GABA) synthesis, a neurotransmitter critically involved in the regulation of gonadotropin secretion.*

N-acetyl-tyrosine : Tyrosine is amongst a class of amino acids known as ‘non-essential’ amino acids, so called because the body can produce them endogenously, and it is therefore not essential to consume dietary tyrosine. That said, tyrosine is also what is known as a conditionally-essential amino acid; conditionally-essential because, along with glucose and ammonia, the synthesis of tyrosine additionally requires adequate levels of phenylalanine. Once synthesized, tyrosine is one of the most critical amino acids, given its prominent role as a substrate in the synthesis of the catecholamines dopamine, norepinephrine, and epinephrine, in addition to both T3 (triiodothyronine) and T4 (thyroxine) thyroid hormones.* 

Choline Bitartrate: Choline is an essential nutrient involved in numerous metabolic pathways, including DNA regulation and repair, protein function, and metabolism. Perhaps most importantly, the critical neurotransmitter acetylcholine is produced directly from free choline via cholinergic neurons. Acetylcholine is then responsible for a number of functions itself, most crucially as the compound which induces muscular contraction, and as the neuromodulator partially responsible for modulating risk/reward, arousal, and supporting memory.*

Tartaric acid occurs naturally in the food source, while its salt derivatives (tartrate, for example) have been used as acidulants, antioxidant synergists, buffers and sequestrants. As free base choline is rapidly destroyed in metabolism, attaching a salt to enhance absorption is necessary. The bitartrate salt addition preserves choline from being destroyed during metabolism. 

1,3,7-trimethylxanthine (Caffeine) and Theobromine (3,7-dimethyl-1H-purine-2,6-dione) 99%: Caffeine and its fellow xanthine and metabolite, theobromine, are some of the most widely consumed, and perhaps some of the most reviewed, psychoactive compounds. Their physiological effects in a range of areas have been well-documented, including exercise performance, information processing, alertness and mood enhancement, attention, and awareness, along with its anti-lipogenic and lipolytic abilities. 

Niacin, also commonly known as nicotinic acid, has been demonstrated to exert potent effects on lipid metabolism; and a significant body of literature exists, focusing on its role as a therapeutic target in that context. In addition to playing a role in supporting healthy HDL cholesterol levels, and rapidly and dose-dependently inducing a decrease in the concentrations of plasma triglycerides, niacin is a powerful vasodilator. 

PURENERGY™ (Caffeine Pterostilbene Complex):

PURENERGY™ is a highly interesting, novel new dietary ingredient created by combining caffeine (at a 43% proportion) with pTeroPure, a 99% pure all-trans pterostilbene (at 53% proportion). 

Pterostilbene is, in turn, itself a highly interesting compound, and the subject of considerable excitement and clinical research within the sports community. Found in small concentrations in blueberries and grapes, pterostilbene is a dimethylated version of the well-known compound resveratrol, and as a consequence, appears to share many of its beneficial physiological effects. Pterostilbene in addition has been hypothesized to exert unique effects in the human body through both genomic and enzymatic pathways, including functioning as a potent antioxidant, as well as playing a role in the regulation of glycolytic/gluconeogenic enzymes such as hexokinase, glucose-6-phosphatase, and fructose-1,6-bisphosphatase.

In combination as PURENERGY™, caffeine and pterostilbene have been the subject of a single, but promising, human trial. The results from this trial demonstrated:

•PURENERGY™ delivers almost 30% more caffeine into the blood than ordinary caffeine. The rate of caffeine absorption is significantly slower with PURENERGY™, by about 30% as compared to ordinary caffeine

Hordenine (N,N-dimethyltyramine) HCl: Hordenine is one of the most favored stimulant ingredients in bodybuilding circles, and has been for some time. Users rave about hordenine, due to its structural similarity with several potent nootropics and stimulants.*

Though limited, some animal research suggest that hordenine may modulate certain brain and nervous system processes, and perhaps regulating the body’s release of and response to noradrenaline. 

Synephrine HCL: Synephrine is a naturally-occurring alkaloid with adrenergic agonist activity, structurally related to epinephrine, norepinephrine, ephedrine, and other compounds with a phenethylamine base structure. Despite its chemical similarity to these compounds, synephrine in its various isomers exerts unique effects on adrenergic receptors, in particular, and the human body, in general. 

Synephrine exists in three isomer forms: para-, meta- and ortho-synephrine. The molecular changes between the three isoforms are minute, but even this small change results in significant alterations to each isomer’s physiological and pharmacokinetic profile. Two of synephrine’s isomers, both p- and m-synephrine, have been shown to naturally occur in mammals (in low concentrations). 

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